Nutramedix – Resveratrol (60 Caps)

Resveratrol's reputation runs ahead of its evidence in many areas. What the research does support is sirtuin activation — specifically SIRT1, a NAD+-dependent deacetylase that regulates gene expression, DNA repair signalling, and cellular stress responses. At 200mg trans-resveratrol per capsule from Japanese Knotweed, this is a clean, well-dosed source without the fillers common in cheaper resveratrol products.

What it supports

• SIRT1 activation — the sirtuin pathway linked to longevity gene expression
• AMPK activation, mimicking the cellular signalling of caloric restriction
• NF-kB inhibition and downstream inflammatory cytokine reduction
• Nrf2 pathway activation, upregulating endogenous antioxidants (superoxide dismutase, catalase)
• Vascular endothelial function and nitric oxide availability via red wine polyphenols
• Direct reactive oxygen species scavenging

Ingredients

Trans-Resveratrol — 200mg (from Japanese Knotweed root, Polygonum cuspidatum)
Red Wine Extract (Vitis vinifera, fruit, standardised to 30% polyphenols) — 25mg

Per 1-capsule serving.

Directions

Take 1 capsule once or twice daily after a meal. Post-meal timing matters: resveratrol is a potent antioxidant and should not be taken immediately before fasting — it can blunt the beneficial oxidative signalling fasting generates. Take it with food, not before a fasted state.

🎧 Listen and learn

🎧 Back to Basics: Slow Down Ageing and Promote Longevity with Dr. Elizabeth Yurth
🎧 Sirtuins and NAD Supplements for Longevity with Dr. Elena Seranova

Why we stock it

NutraMedix uses 200mg trans-resveratrol per capsule from Japanese Knotweed — the plant source with the highest natural stilbene concentration. The red wine polyphenol co-extract adds endothelial and vascular support alongside the sirtuin pathway activity. One clinical note worth knowing: because resveratrol is a strong antioxidant, taking it fasted or before exercise can interfere with the hormetic oxidative signal those states generate. Post-meal is the correct window. I recommend it as part of a NAD+ pathway stack — resveratrol as the SIRT1 activator, alongside NMN or NR as the substrate.

NutraMedix is a US-based company (Florida).